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 Clinical Research in Autism


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In honor and in memory

of Dr. Bernard Rimland,

Autism Pioneer and Advocate

 Issue: # 28                           


Dear Subscriber,


This e-newsletter provides obstetricians, pediatricians, and nurses with links to the latest research on ways to understand and to help children and adults on the autism spectrum.  Please feel free to send us your comments and feedback to: [email protected]


Previous issues of this e-newsletter can be viewed at:


Steve Edelson, Ph.D. and Lenny Schafer

Gastrointestinal Problems in Autism

The Autism Research Institute held its first think tank in 1995, and a large part of the discussion was centered on the possibility that gastrointestinal (GI) problems may be common in individuals on the autism spectrum. According to Dr. Bernard Rimland, this was the first time that a group of researchers and clinicians discussed GI problems associated with autism. 
During the meeting, clinicians reported observing many patients on the autism spectrum who were suffering from constipation, diarrhea, and GERD. At the end of the meeting, there was general consensus that the autism research community should investigate the underlying reasons as well as ways to treat GI issues in these individuals.
Recently, several studies have been published that shed light on this important issue. See below.
Diagnosis and Risks
Pregnant Woman2 
[Original article appeared in PLOS One]
Researchers identified a signature brain-wave pattern for children with ASD related to genetic condition known as Dup15q syndrome
Compulsions, anxiety replace autism in some children
[Original article appeared in Pediatrics International]
Partner preferences may contribute to autism prevalence
[Original article appeared in JAMA Psychiatry]
Rare form of autism linked to lack of key nutrient
[Original article appeared in Cell]
Gastrointestinal Research

Changes in blood-brain barrier, intestinal permeability found in individuals with autism
[Original article appeared in Molecular Autism]

[Original article appeared in  Journal of Perinatology]
Increased reaction to stress linked to gastrointestinal issues in children with autism
[Original article appeared in Brain, Behavior, and Immunity, the journal of the Psychoneuroimmunology Research Society]
New Autism Treatment Could Come from Altering Gut Microbiota
[Original article appeared in Microbiome]
Autism Research Institute, 4182 Adams Ave, San Diego, CA 92116